PKP2 and DSG1

Data Source:
HPRD (two hybrid, in vivo)

		PKP2	DSG1
Description		plakophilin 2	desmoglein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Messenger Ribonucleoprotein Complex	Cornified Envelope Cytosol Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Calcium Ion Binding Protein Binding Toxic Substance Binding Gamma-catenin Binding
	Biological Process	Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Heart Development Positive Regulation Of Sodium Ion Transport Keratinization Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Cornification Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Keratinization Response To Progesterone Neutrophil Degranulation Protein Stabilization Maternal Process Involved In Female Pregnancy Cornification Cell-cell Adhesion
Pathways		Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Striate palmoplantar keratoderma
GWAS		Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 32201043 27182965) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)	Eosinophilic esophagitis (pediatric) ( 20208534) perceptual and visual search speed (trail making test A) (age interaction) ( 24629169) Yeast infection ( 28928442)
Interacting Genes		40 interacting genes: ACTN3 AKAP9 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTNNB1 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 JUP KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 ROPN1 SMAD9 SPTA1 TEKT4 YWHAG	8 interacting genes: CDC42 DSC1 DSC2 JUP KLK5 PKP1 PKP2 PKP3
Entrez ID		5318	1828
HPRD ID		04177	00515
Ensembl ID		ENSG00000057294	ENSG00000134760
Uniprot IDs		Q99959	Q02413
PDB IDs		3TT9
Enriched GO Terms of Interacting Partners?
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