DSG1 and KLK5

Data Source:
HPRD (in vitro)

		DSG1	KLK5
Description		desmoglein 1	kallikrein related peptidase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Cytosol Secretory Granule Epidermal Lamellar Body
	Molecular Function	Calcium Ion Binding Protein Binding Toxic Substance Binding Gamma-catenin Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity
	Biological Process	Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Keratinization Response To Progesterone Neutrophil Degranulation Protein Stabilization Maternal Process Involved In Female Pregnancy Cornification Cell-cell Adhesion	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cornification Amelogenesis
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope	Formation of the cornified envelope Formation of the cornified envelope
Drugs
Diseases		Striate palmoplantar keratoderma
GWAS		Eosinophilic esophagitis (pediatric) ( 20208534) perceptual and visual search speed (trail making test A) (age interaction) ( 24629169) Yeast infection ( 28928442)
Interacting Genes		8 interacting genes: CDC42 DSC1 DSC2 JUP KLK5 PKP1 PKP2 PKP3	12 interacting genes: AURKA BAG4 CASP8 DSG1 ERBB2 ESR1 IGF1R MANBAL NOTCH2 SERPINA1 TGFB1 TSG101
Entrez ID		1828	25818
HPRD ID		00515	05732
Ensembl ID		ENSG00000134760	ENSG00000167754
Uniprot IDs		Q02413	Q9Y337
PDB IDs			2PSX 2PSY 6QFE
Enriched GO Terms of Interacting Partners?
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