PKP2 and TEKT4

Data Source:
BioGRID (two hybrid)

		PKP2	TEKT4
Description		plakophilin 2	tektin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Messenger Ribonucleoprotein Complex	Nucleus Microtubule Cytoskeleton Sperm Flagellum
	Molecular Function	Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Protein Binding
	Biological Process	Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Heart Development Positive Regulation Of Sodium Ion Transport Keratinization Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Cornification Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Cilium Assembly Cilium Movement Involved In Cell Motility
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 32201043 27182965) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)
Interacting Genes		40 interacting genes: ACTN3 AKAP9 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTNNB1 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 JUP KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 ROPN1 SMAD9 SPTA1 TEKT4 YWHAG	104 interacting genes: ACBD4 AKAP8L ALAS1 AMMECR1 ANKRD55 ARID5A ATG5 BCL6 BLZF1 BORCS8-MEF2B C11orf1 C1orf109 C9orf24 CTDSP1 DDIT4L EFHC2 EYA2 FAM220A GATA1 GPSM1 GRB10 GSE1 HCK HNRNPH1 HNRNPM HOXA1 HOXB5 HOXC8 IKZF3 INCA1 KPRP KRT15 KRT18 KRT34 KRT35 KRT75 KRT86 KRTAP11-1 KRTAP13-1 KRTAP13-3 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP26-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LASP1 LMCD1 LNX1 MAGEA4 MIIP MORN3 MYOZ3 NANOS3 NFKBID NR5A1 PCSK5 PHF11 PKP2 PLAGL2 POLDIP3 PPP1R13B PPP1R32 PRDM14 PRDM6 PROP1 PSMA1 PTH1R RAMAC RARA RBM48 RECK RFX6 RUSC1 SCN5A SLC25A6 SMAD3 SOCS4 SPATA8 SPATC1L SPG21 SUV39H1 TADA2A TEKT1 TFAP4 TOX2 TRIB3 TRIP6 TSPAN4 UBASH3A USP2 VGLL1 ZFP90 ZIM2 ZMYND12 ZNF20 ZNF417 ZNF426 ZNF474 ZNF552 ZNF581 ZNF655 ZNF688
Entrez ID		5318	150483
HPRD ID		04177	14518
Ensembl ID		ENSG00000057294	ENSG00000163060
Uniprot IDs		Q99959	A0A384MEB7 Q8WW24
PDB IDs		3TT9
Enriched GO Terms of Interacting Partners?
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