SERPINB9 and GZMB

Data Source:
HPRD (in vitro)

		SERPINB9	GZMB
Description		serpin family B member 9	granzyme B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Immunological Synapse Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Mast Cell Mediated Immunity Apoptotic Process Immune Response Response To Bacterium Positive Regulation Of Gene Expression Negative Regulation Of Endopeptidase Activity Negative Regulation By Symbiont Of Host Apoptotic Process Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Estrogen Stimulus	Apoptotic Process Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways			NOTCH2 intracellular domain regulates transcription Activation, myristolyation of BID and translocation to mitochondria
Drugs		Raloxifene
Diseases
GWAS		Plateletcrit ( 32888494) Vitiligo ( 27723757)	Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)
Interacting Genes		28 interacting genes: BRD7 CASP1 CASP4 CCDC90B COPS6 CRMP1 ECH1 EEF1A1 ERG28 GAPDH GBP2 GDF9 GZMB IGSF21 LRIF1 MED31 PLEKHM1 PRPF40A RBM48 SETDB1 TLE1 TP53 TRAF5 TUBB2A UBR1 UNC119 XRCC6 ZHX1	26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		5272	3002
HPRD ID		03480	00476
Ensembl ID		ENSG00000170542	ENSG00000100453
Uniprot IDs		A0A024QZT4 P50453	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs			1FQ3 1IAU
Enriched GO Terms of Interacting Partners?
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