CFP and SMARCC1

Data Source:
BioGRID (two hybrid)

		CFP	SMARCC1
Description		complement factor properdin	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Specific Granule Lumen Collagen-containing Extracellular Matrix Tertiary Granule Lumen	Chromatin XY Body Nucleus Nucleoplasm Cytoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex
	Molecular Function	Protein Binding	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding Protein N-terminus Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Defense Response To Bacterium Neutrophil Degranulation	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Prostate Gland Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Alternative complement activation Activation of C3 and C5 Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins Neutrophil degranulation Regulation of Complement cascade	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases		Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS			Household income (MTAG) ( 31844048) Renal underexcretion gout ( 32238385) Systolic blood pressure ( 31928498)
Interacting Genes		32 interacting genes: BANF2 C3 CFAP206 CFB CYSRT1 FHL5 FKBP6 GEMIN4 GNE HEXIM2 HOXA1 KCTD9 KLHL38 KRTAP11-1 KRTAP12-2 KRTAP3-1 KRTAP6-2 LCE1A LONRF1 MID2 MTOR NEK6 NOXA1 PRKAB2 RECK SMARCC1 SPAG8 STK16 TRIP13 VENTX ZNF330 ZNF414	53 interacting genes: ADAMTSL4 ADD1 AKT1 CCNE1 CEBPB CFP CIDEB CYSRT1 EWSR1 FANCA FUS GATA1 GLRX3 GSTO2 ITCH KLF1 KRTAP13-3 KRTAP19-2 KRTAP21-2 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LRP2BP MGAT5B MSL1 MYC NCOA1 NEDD4 NONO NR3C1 OTX1 PLSCR1 PPIP5K2 PRMT5 PTH1R RELB SIN3A SLC15A2 SMARCA4 SMARCD3 SP1 SPATA12 TAF15 TRIM42 UFSP1 VGLL3 ZNF581
Entrez ID		5199	6599
HPRD ID		02308	03435
Ensembl ID		ENSG00000126759	ENSG00000173473
Uniprot IDs		A0A0S2Z4I5 P27918	Q58EY4 Q92922
PDB IDs		1W0R 1W0S 6RUR 6RUS 6RUV 6RV6 6S08 6S0A 6S0B 6SEJ	2YUS 5GJK 6KZ7
Enriched GO Terms of Interacting Partners?
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