CFP and LCE1A

Data Source:
BioGRID (two hybrid)

		CFP	LCE1A
Description		complement factor properdin	late cornified envelope 1A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Specific Granule Lumen Collagen-containing Extracellular Matrix Tertiary Granule Lumen	Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Defense Response To Bacterium Neutrophil Degranulation	Cornification
Pathways		Alternative complement activation Activation of C3 and C5 Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins Neutrophil degranulation Regulation of Complement cascade	Formation of the cornified envelope
Drugs
Diseases		Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS			Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		32 interacting genes: BANF2 C3 CFAP206 CFB CYSRT1 FHL5 FKBP6 GEMIN4 GNE HEXIM2 HOXA1 KCTD9 KLHL38 KRTAP11-1 KRTAP12-2 KRTAP3-1 KRTAP6-2 LCE1A LONRF1 MID2 MTOR NEK6 NOXA1 PRKAB2 RECK SMARCC1 SPAG8 STK16 TRIP13 VENTX ZNF330 ZNF414	69 interacting genes: ADAMTSL4 AQP1 CCN3 CFP CHIC2 CYSRT1 EFEMP2 FBLN1 FUCA2 GRN HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP21-2 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LCE5A MDFI MESD NBPF19 NID2 NOTCH2NLA PLA2G10 PLAC8 PLSCR2 PLSCR4 RGS17 RGS20 SLC39A7 SMCP SPRY1 SPRY2 SPRY3 TGFB1 TRIM42 TSPAN4 VWC2 VWC2L
Entrez ID		5199	353131
HPRD ID		02308	13966
Ensembl ID		ENSG00000126759	ENSG00000186844
Uniprot IDs		A0A0S2Z4I5 P27918	Q5T7P2
PDB IDs		1W0R 1W0S 6RUR 6RUS 6RUV 6RV6 6S08 6S0A 6S0B 6SEJ
Enriched GO Terms of Interacting Partners?
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