PDGFB and PDGFRA

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		PDGFB	PDGFRA
Description		platelet derived growth factor subunit B	platelet derived growth factor receptor alpha
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Cell Surface Basolateral Plasma Membrane Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cilium External Side Of Plasma Membrane Membrane Cell Junction Intrinsic Component Of Plasma Membrane Protein-containing Complex Receptor Complex
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding Growth Factor Receptor Binding	Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Growth Factor Binding Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Protein-containing Complex Binding Platelet-derived Growth Factor Binding
	Biological Process	MAPK Cascade Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Platelet Degranulation Positive Regulation Of Glomerular Filtration Protein Phosphorylation Heart Development Positive Regulation Of Cell Population Proliferation Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Hemopoiesis Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Protein Binding Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Interleukin-18-mediated Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Paracrine Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration	MAPK Cascade Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Estrogen Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Platelet Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Leydig Cell Differentiation Positive Regulation Of Kinase Activity Cellular Response To Reactive Oxygen Species Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis White Fat Cell Differentiation Regulation Of Chemotaxis Positive Regulation Of Protein Kinase B Signaling Cardiac Myofibril Assembly Roof Of Mouth Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Platelet degranulation PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer Non-integrin membrane-ECM interactions RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Imatinib-resistant PDGFR mutants Sunitinib-resistant PDGFR mutants Regorafenib-resistant PDGFR mutants Sorafenib-resistant PDGFR mutants PDGFR mutants bind TKIs
Drugs		Pegpleranib	Becaplermin Imatinib Sunitinib XL820 Olaratumab Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin keratinocyte (neonatal) Fostamatinib Erdafitinib Amuvatinib Ripretinib
Diseases		Malignant pleural mesothelioma Glioma	Glioma
GWAS		Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000)	Adult asthma ( 27611488) Asthma ( 27611488) Blood protein levels ( 30072576) Cadmium levels ( 26025379) Core binding factor acute myeloid leukemia ( 27903959) Corneal astigmatism ( 22144915 29422769) Corneal curvature ( 24963161 23401653 21665993) Height ( 18193045) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lupus nephritis in systemic lupus erythematosus ( 24925725) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 29403010 20139978) Mean corpuscular volume ( 29403010 20139978) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30578418) Red blood cell count ( 29403010 28453575 20139978) Serum VEGFR2 concentration ( 25411163) Systolic blood pressure ( 30578418) Uterine fibroids ( 30194396 31649266) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		23 interacting genes: A2M ART1 BCCIP COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 FBXO7 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB PIK3R1 SPARC THBS1	64 interacting genes: AKT1 ARNT AURKA BECN1 CAV1 CAV3 CBL CCND2 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CRK CRKL EGFR EPHA2 ERBB2 ERBB3 FBXO25 FGFR4 FZR1 GRB14 GRM1 HGF ITGAV ITGB3 JAK1 KASH5 KDELR2 LATS2 MAP2K5 MYC NF2 PDGFA PDGFB PDGFC PDGFRB PIK3CA PIK3R1 PLCG1 PLPP6 PRMT5 PTPN11 RAF1 SHB SHF SLC9A3R1 SMURF1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B STK11 TERT TGFBR2 TP53 TTYH2 ULBP2
Entrez ID		5155	5156
HPRD ID		01815	01429
Ensembl ID		ENSG00000100311	ENSG00000134853
Uniprot IDs		A0A384NYY3 P01127	P16234
PDB IDs		1PDG 3MJG 4HQU 4HQX 4QCI	1GQ5 5GRN 5K5X 6A32 6JOI 6JOJ 6JOK 6JOL
Enriched GO Terms of Interacting Partners?
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