TMX2 and ITGAM

Data Source:
BioGRID (two hybrid)

		TMX2	ITGAM
Description		thioredoxin related transmembrane protein 2	integrin subunit alpha M
Image
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Membrane-bounded Organelle Mitochondria-associated Endoplasmic Reticulum Membrane	Extracellular Space Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Integrin AlphaM-beta2 Complex Specific Granule Membrane Plasma Membrane Raft Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Protein Binding Disulfide Oxidoreductase Activity Identical Protein Binding	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Heat Shock Protein Binding Cargo Receptor Activity Metal Ion Binding
	Biological Process	Brain Development	Microglial Cell Activation Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Forebrain Development Positive Regulation Of Superoxide Anion Generation Toll-like Receptor 4 Signaling Pathway Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Innate Immune Response Negative Regulation Of Dopamine Metabolic Process Leukocyte Migration Positive Regulation Of Protein Targeting To Membrane Apoptotic Signaling Pathway Amyloid-beta Clearance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Hippocampal Neuron Apoptotic Process Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death Positive Regulation Of Microglial Cell Mediated Cytotoxicity Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways			Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Problematic alcohol use ( 32451486) Reticulocyte count ( 32888494) Schizophrenia ( 25056061 29483656)	Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Graves' disease ( 22922229) IgA nephropathy ( 25305756) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 27399966 18204446 24871463 26606652 23273568 26502338 18204098 21408207 19165918 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Interacting Genes		164 interacting genes: AGPAT3 AGPAT4 AGPAT5 AIG1 AQP6 ARV1 ASGR1 ASPH ATXN1 BDKRB1 BET1 BNIP1 BNIP2 BNIP3 BRICD5 BTN2A2 C2CD2L C3orf52 CCDC167 CCL2 CD81 CDIPT CDS2 CMTM7 COL8A2 COMMD8 COX20 CTSA CTXN3 CXCL16 CXorf66 CYBC1 CYP4F2 DERL1 DGAT2L6 EMD EMP3 F2RL1 FA2H FAM177A1 FAM241B FAM3C FAXDC2 FDFT1 FUNDC2 FXYD6-FXYD2 GIMAP1 GIMAP5 GJB2 HACD2 HHATL HMOX2 HSD17B11 HSD17B13 HSD3B7 HTATIP2 IER3 IER3IP1 IGFBP5 INSIG2 ITGAM LEPROT LEPROTL1 LHFPL5 LRAT MALL MFF MFSD14B MGLL MGST3 MIP MLN MS4A1 MTNR1A NAT8 NDUFA3 NINJ2 NRM NSDHL NSG1 ORMDL2 OTULINL PAEP PEDS1-UBE2V1 PEX16 PKMYT1 PLP2 PNLIPRP1 PRAF2 PRB1 PTAFR PTPN9 RABAC1 REEP2 REEP4 RFT1 RNF24 RTP2 RUSF1 SACM1L SCAMP5 SCD SELENOK SERF1A SERF1B SERP2 SFT2D1 SFXN1 SFXN3 SLC22A18 SLC22A2 SLC29A2 SLC35A1 SMAGP SMCO4 SMIM1 STATH STX12 STX3 STX7 THBD THSD7B TMBIM6 TMEM115 TMEM120A TMEM120B TMEM121 TMEM128 TMEM140 TMEM14B TMEM14C TMEM176A TMEM201 TMEM203 TMEM208 TMEM222 TMEM239 TMEM254 TMEM31 TMEM50B TMEM51 TMEM65 TMEM71 TMEM86B TMEM97 TPRG1 TRAM1L1 TREX1 TSNARE1 TSPAN2 TVP23B UBE2J1 UNC93A VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB WFDC2 YIF1A YIPF1 YIPF2 YIPF6	55 interacting genes: ABHD16A AQP6 ARL13B AUP1 C3 CD209 CD79A CERS4 CFH CLEC4M CLRN1 CREB3L1 DKK4 ELANE ELOVL4 ERGIC3 FGG GJA8 GJB1 GORAB GP1BA GPR42 HP HSD17B13 ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 KASH5 KCNJ6 KIR2DL3 LMNA MGST3 MMGT1 MRM1 MUC1 PGRMC2 PIGP PLAUR REEP2 REEP4 RUSF1 SCN3B SHARPIN SLC10A6 SLC35C2 SYT2 THY1 TMEM14B TMEM229B TMEM31 TMEM52B TMX2
Entrez ID		51075	3684
HPRD ID		07159	00411
Ensembl ID		ENSG00000213593	ENSG00000169896
Uniprot IDs		Q9Y320	P11215
PDB IDs		2DJ0	1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76 4XW2 6RHW
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?