ITGAM and GPR42

Data Source:
BioGRID (two hybrid)

		ITGAM	GPR42
Description		integrin subunit alpha M	G protein-coupled receptor 42
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Integrin AlphaM-beta2 Complex Specific Granule Membrane Plasma Membrane Raft Extracellular Exosome Tertiary Granule Membrane	Integral Component Of Plasma Membrane
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Heat Shock Protein Binding Cargo Receptor Activity Metal Ion Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Microglial Cell Activation Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Forebrain Development Positive Regulation Of Superoxide Anion Generation Toll-like Receptor 4 Signaling Pathway Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Innate Immune Response Negative Regulation Of Dopamine Metabolic Process Leukocyte Migration Positive Regulation Of Protein Targeting To Membrane Apoptotic Signaling Pathway Amyloid-beta Clearance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Hippocampal Neuron Apoptotic Process Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death Positive Regulation Of Microglial Cell Mediated Cytotoxicity Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling Positive Regulation Of Prostaglandin-E Synthase Activity	G Protein-coupled Receptor Signaling Pathway
Pathways		Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Graves' disease ( 22922229) IgA nephropathy ( 25305756) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 27399966 18204446 24871463 26606652 23273568 26502338 18204098 21408207 19165918 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Interacting Genes		55 interacting genes: ABHD16A AQP6 ARL13B AUP1 C3 CD209 CD79A CERS4 CFH CLEC4M CLRN1 CREB3L1 DKK4 ELANE ELOVL4 ERGIC3 FGG GJA8 GJB1 GORAB GP1BA GPR42 HP HSD17B13 ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 KASH5 KCNJ6 KIR2DL3 LMNA MGST3 MMGT1 MRM1 MUC1 PGRMC2 PIGP PLAUR REEP2 REEP4 RUSF1 SCN3B SHARPIN SLC10A6 SLC35C2 SYT2 THY1 TMEM14B TMEM229B TMEM31 TMEM52B TMX2	104 interacting genes: ADIPOQ ALOX5AP ANKRD46 APOD ATP13A1 ATP4B ATP6V0B ATP6V0C BNIP3 BTN2A2 C1GALT1 CCDC167 CCL4L2 CD300C CD79A CLCA4 CLEC2D COMT CTXN3 CXCL16 CXCL9 DRAM1 EFNA5 EMP1 ERMP1 FAM3C FXYD3 FXYD6 GJB2 GOSR2 GPR37L1 GYPC IER3IP1 IGFBP5 IL1RL1 ITGAM JPH1 KCNA1 KLRG1 LAT LEPROTL1 LHFPL5 LNPEP LTC4S MFSD5 MFSD6 MGAM MS4A1 NDUFB11 NINJ2 NRM NSG1 PAEP PLP1 PLPP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SCD SERINC1 SERP2 SERTM1 SLC30A2 SLC30A3 SLC30A8 SLC35E4 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC41A2 SMCO4 SMIM3 STATH STRIT1 STX8 SYNDIG1 SYNGR1 TEX264 TF TM4SF4 TMBIM6 TMEM140 TMEM147 TMEM182 TMEM19 TMEM237 TMEM239 TMEM242 TMEM262 TMEM30B TMEM60 TMEM65 TRARG1 TREX1 TSPO2 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZFPL1
Entrez ID		3684	2866
HPRD ID		00411	16033
Ensembl ID		ENSG00000169896	ENSG00000126251
Uniprot IDs		P11215	A0A0K0PUY3 O15529
PDB IDs		1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76 4XW2 6RHW
Enriched GO Terms of Interacting Partners?
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