MED31 and LAMA4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED31	LAMA4
Description		mediator complex subunit 31	laminin subunit alpha 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex Core Mediator Complex	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Fibroblast Proliferation Limb Development	Cell Adhesion Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Regulation Of Embryonic Development Negative Regulation Of Cold-induced Thermogenesis
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans MET activates PTK2 signaling
Drugs
Diseases
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Bipolar disorder ( 31043756) Metabolite levels ( 23823483)
Interacting Genes		59 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1	17 interacting genes: APC ATF7IP BRD7 COPS6 EEF1A1 FHL1 GAPDH LRIF1 MED31 PTN RTN4 RTP2 TP53 TUBB2A UBR1 UNC119 ZHX1
Entrez ID		51003	3910
HPRD ID		14382	02532
Ensembl ID		ENSG00000108590	ENSG00000112769
Uniprot IDs		Q9Y3C7	A0A0A0MQS9 A0A0A0MTC7 Q16363 Q5D044
PDB IDs
Enriched GO Terms of Interacting Partners?
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