MED31 and CCT7

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED31	CCT7
Description		mediator complex subunit 31	chaperonin containing TCP1 subunit 7
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex Core Mediator Complex	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Fibroblast Proliferation Limb Development	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	General cognitive ability ( 29844566)
Interacting Genes		59 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1	22 interacting genes: ANXA1 ANXA7 APP ATP5F1C CDKN1A CEBPE CRMP1 DNM2 EEF1G KAT5 KRAS LINC01554 MED31 NHLH1 NKX3-1 PRPF40A RAP1B RCC1 SUMO4 TCP1 WBP2 ZNRD2
Entrez ID		51003	10574
HPRD ID		14382	06896
Ensembl ID		ENSG00000108590	ENSG00000135624
Uniprot IDs		Q9Y3C7	Q99832
PDB IDs			6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?