ATP2B2 and DLG2

Data Source:
HPRD (in vivo, in vitro)

		ATP2B2	DLG2
Description		ATPase plasma membrane Ca2+ transporting 2	discs large MAGUK scaffold protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome Presynapse Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse	Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Neuromuscular Junction Neuron Projection Perikaryon Juxtaparanode Region Of Axon Postsynaptic Density Membrane Axon Cytoplasm
	Molecular Function	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism Protein Binding Calmodulin Binding ATP Binding ATPase-coupled Cation Transmembrane Transporter Activity PDZ Domain Binding Metal Ion Binding Calcium-transporting ATPase Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Calcium-transporting ATPase Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	Guanylate Kinase Activity Protein Binding Kinase Binding
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Sensory Perception Of Sound Neuron Differentiation Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction	MAPK Cascade Chemical Synaptic Transmission Embryo Development Negative Regulation Of Phosphatase Activity Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport Regulation Of NMDA Receptor Activity
Pathways		Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Halothane Desflurane
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Cognitive decline rate in late mild cognitive impairment ( 26252872) Manganese levels ( 26025379) Metabolite levels ( 19043545)	Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Attention function in attention deficit hyperactive disorder ( 26174813) BMI at adiposity rebound ( 31840077) Body fat mass ( 28552196) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronic obstructive pulmonary disease ( 25584925) Chronic periodontitis ( 25008200) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Migraine without aura ( 28952330) Mild influenza (H1N1) infection ( 26379185) Modic changes ( 30808802) Myopia ( 27182965) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pallidum volume ( 31530798) Parkinson's disease ( 25064009 32201043 28892059 28011712 17052657 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Phospholipid levels (plasma) ( 22359512) Pork consumption ( 32066663) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein quantitative trait loci ( 18464913) Putamen volume ( 29147026) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Schizophrenia ( 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical brain region volumes ( 25607358) Trunk fat mass ( 28552196) Type 2 diabetes ( 31049640) Urate levels in overweight individuals ( 25811787) Weight ( 28552196) Wilms tumor ( 22544364)
Interacting Genes		8 interacting genes: DLG1 DLG2 DLG4 ERBIN PDZD11 PRKCA SLC9A3R2 SNTA1	52 interacting genes: ABCA1 AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VTN WNT3A
Entrez ID		491	1740
HPRD ID		00160	04663
Ensembl ID		ENSG00000157087	ENSG00000150672
Uniprot IDs		A0A024R2E4 Q01814 Q4LE63	B7Z2T4 Q15700
PDB IDs			2BYG 2HE2
Enriched GO Terms of Interacting Partners?
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