DLG2 and WNT3A

Data Source:
HPRD (two hybrid)

		DLG2	WNT3A
Description		discs large MAGUK scaffold protein 2	Wnt family member 3A
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Neuromuscular Junction Neuron Projection Perikaryon Juxtaparanode Region Of Axon Postsynaptic Density Membrane Axon Cytoplasm	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Early Endosome Membrane Extracellular Exosome Presynapse Glutamatergic Synapse Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	Guanylate Kinase Activity Protein Binding Kinase Binding	Transcription Coactivator Activity Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Co-receptor Binding Receptor Ligand Activity
	Biological Process	MAPK Cascade Chemical Synaptic Transmission Embryo Development Negative Regulation Of Phosphatase Activity Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport Regulation Of NMDA Receptor Activity	Osteoblast Differentiation In Utero Embryonic Development Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Heart Looping Positive Regulation Of Receptor Internalization Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway Axon Guidance Cell Population Proliferation Positive Regulation Of Cell Population Proliferation COP9 Signalosome Assembly Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Hemopoiesis Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Cell Proliferation In Midbrain Cellular Protein Localization Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Synaptic Vesicle Recycling Inner Ear Morphogenesis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Somatic Stem Cell Division Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Dermatome Development Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Secondary Palate Development Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Presynapse Assembly Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Neuron Death Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Core Promoter Binding Beta-catenin Destruction Complex Disassembly Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Attention function in attention deficit hyperactive disorder ( 26174813) BMI at adiposity rebound ( 31840077) Body fat mass ( 28552196) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronic obstructive pulmonary disease ( 25584925) Chronic periodontitis ( 25008200) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Migraine without aura ( 28952330) Mild influenza (H1N1) infection ( 26379185) Modic changes ( 30808802) Myopia ( 27182965) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pallidum volume ( 31530798) Parkinson's disease ( 25064009 32201043 28892059 28011712 17052657 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Phospholipid levels (plasma) ( 22359512) Pork consumption ( 32066663) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein quantitative trait loci ( 18464913) Putamen volume ( 29147026) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Schizophrenia ( 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical brain region volumes ( 25607358) Trunk fat mass ( 28552196) Type 2 diabetes ( 31049640) Urate levels in overweight individuals ( 25811787) Weight ( 28552196) Wilms tumor ( 22544364)	Birth weight ( 31043758) Diastolic blood pressure ( 28135244) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		52 interacting genes: ABCA1 AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VTN WNT3A	11 interacting genes: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2
Entrez ID		1740	89780
HPRD ID		04663	05897
Ensembl ID		ENSG00000150672	ENSG00000154342
Uniprot IDs		B7Z2T4 Q15700	P56704
PDB IDs		2BYG 2HE2
Enriched GO Terms of Interacting Partners?
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