NRF1 and KHDC4

Data Source:
BioGRID (two hybrid)

		NRF1	KHDC4
Description		nuclear respiratory factor 1	KH domain containing 4, pre-mRNA splicing factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity	RNA Binding Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II	MRNA Splice Site Selection
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC22A18AS SP2 SP4 SPSB2 SRARP TESMIN TEX43 TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6	21 interacting genes: BANP C14orf119 DNAJC5 KCNIP3 MAGEA12 NRF1 NUTF2 PIDD1 PRKAB2 PRR13 PSMB1 PUF60 QRICH1 RBM23 RBM39 RHOXF2 SAT1 SPANXN2 U2AF2 ZDHHC17 ZRSR2
Entrez ID		4899	22889
HPRD ID		02930	17198
Ensembl ID		ENSG00000106459	ENSG00000132680
Uniprot IDs		A0A024R770 A0A024R774 Q16656	Q7Z7F0
PDB IDs			2YQR
Enriched GO Terms of Interacting Partners?
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