NRF1 and PANX2

Data Source:
BioGRID (two hybrid)

		NRF1	PANX2
Description		nuclear respiratory factor 1	pannexin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Cytoplasm Plasma Membrane Gap Junction Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity	Structural Molecule Activity Wide Pore Channel Activity Gap Junction Hemi-channel Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II	Response To Ischemia Cation Transport Cell-cell Signaling Positive Regulation Of Interleukin-1 Production Transmembrane Transport
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis	Electric Transmission Across Gap Junctions
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)	Acne (severe) ( 24927181)
Interacting Genes		48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC22A18AS SP2 SP4 SPSB2 SRARP TESMIN TEX43 TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6	3 interacting genes: ATXN1 BANP NRF1
Entrez ID		4899	56666
HPRD ID		02930	09760
Ensembl ID		ENSG00000106459	ENSG00000073150
Uniprot IDs		A0A024R770 A0A024R774 Q16656	B3KTT7 Q495U3 Q96RD6
PDB IDs
Enriched GO Terms of Interacting Partners?
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