CNOT2 and TEKT3

Data Source:
BioGRID (two hybrid)

		CNOT2	TEKT3
Description		CCR4-NOT transcription complex subunit 2	tektin 3
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex	Acrosomal Membrane Outer Acrosomal Membrane Nucleus Microtubule Cytoskeleton Sperm Flagellum Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II Regulation Of Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Population Maintenance	Flagellated Sperm Motility Cilium Assembly Cilium Movement Involved In Cell Motility Regulation Of Brood Size
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369) Triglyceride levels ( 32154731)	Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)
Interacting Genes		26 interacting genes: ARMC5 BCL6 BEX1 C11orf1 C20orf85 CCHCR1 CNOT1 CNOT3 CNOT4 CNOT8 CSTF2 DDB1 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3	33 interacting genes: AJUBA ARID5A ASPG ATN1 CALCOCO2 CNOT2 DDI1 GORASP2 HNRNPH1 IKZF3 INSC KRT34 KRTAP15-1 KRTAP19-5 KRTAP26-1 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LASP1 LMO2 METTL27 OIP5 PLAGL2 PLEKHG4 RAMAC RFX6 SPAG8 TEX45 TNS2 TRAF2 TRIB3 WWOX
Entrez ID		4848	64518
HPRD ID		05367	18173
Ensembl ID		ENSG00000111596	ENSG00000125409
Uniprot IDs		A0A024RBD8 B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8	Q9BXF9
PDB IDs		4C0D 4C0F 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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