CNOT2 and PRR35

Data Source:
BioGRID (two hybrid)

		CNOT2	PRR35
Description		CCR4-NOT transcription complex subunit 2	proline rich 35
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II Regulation Of Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Population Maintenance
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369) Triglyceride levels ( 32154731)
Interacting Genes		26 interacting genes: ARMC5 BCL6 BEX1 C11orf1 C20orf85 CCHCR1 CNOT1 CNOT3 CNOT4 CNOT8 CSTF2 DDB1 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3	80 interacting genes: ABHD11 ACY1 APPL2 ARMC5 ASB15 BEGAIN BIRC7 BPIFA1 C11orf1 C19orf54 CARD10 CCDC136 CNOT2 CRX CYSRT1 EXOC8 FAM168B FHL3 FRYL GIGYF1 GRAP2 HOMER3 HOOK2 HPCA HSPB2 HSPB2-C11orf52 INSC INTS11 JUP KLHL26 KRT31 KRT34 KRT35 KRTAP10-7 KRTAP12-1 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LONRF1 LZTS2 MAGED1 MCCD1 MKRN3 MSS51 MTUS2 N4BP3 NBPF19 NOTCH2NLA OIP5 OXER1 PFDN5 PLAGL2 PPIL1 PPP1R13B PRR20A PRR20B PRR20C PRR20D PRR20E PSTPIP1 RBPMS RNF144B RUSC1 SMUG1 SPAG8 TBX19 TLE5 TRIM27 TRIM54 TRIM73 TTC19 TTLL12 UBASH3B UBXN11 USP54 ZMYND12 ZNF655
Entrez ID		4848	146325
HPRD ID		05367	10046
Ensembl ID		ENSG00000111596	ENSG00000161992
Uniprot IDs		A0A024RBD8 B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8	P0CG20
PDB IDs		4C0D 4C0F 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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