MX1 and PSD3

Data Source:
BioGRID (two hybrid)

		MX1	PSD3
Description		MX dynamin like GTPase 1	pleckstrin and Sec7 domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Axon Cytoplasmic Vesicle Nuclear Membrane Mitochondrial Membrane Dendritic Spine Head Perinuclear Region Of Cytoplasm Presynapse Postsynaptic Endocytic Zone Membrane	Postsynaptic Density Ruffle Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding
	Biological Process	Mitochondrial Fission Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of Synapse Structure Or Activity Defense Response To Virus Type I Interferon Signaling Pathway Membrane Fusion Postsynaptic Neurotransmitter Receptor Internalization	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Body fat mass ( 28552196) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Bone ultrasound measurement (velocity of sound) ( 28472463) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery disease ( 33020668) Erythrocyte cadmium concentration in never smokers ( 27005419) Glucose homeostasis traits ( 30576415) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longitudinal cocaine use ( 31591132) Neutrophil count ( 21507922) Obesity-related traits ( 23251661) Paclitaxel-induced neuropathy ( 23776197) Perceived intensity of fructose ( 31005972) Schizophrenia ( 30285260) Sub-cortical grey matter volume ( 31530798) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Triglyceride levels ( 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Trunk fat mass ( 28552196) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)
Interacting Genes		41 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623	2 interacting genes: ARAP1 MX1
Entrez ID		4599	23362
HPRD ID		00919	11462
Ensembl ID		ENSG00000157601	ENSG00000156011
Uniprot IDs		P20591	B3KRC4 Q9NYI0
PDB IDs		3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM
Enriched GO Terms of Interacting Partners?
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