MUTYH and TNFRSF9

Data Source:
HPRD (in vitro, in vivo)

		MUTYH	TNFRSF9
Description		mutY DNA glycosylase	TNF receptor superfamily member 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding Cytokine Binding Signaling Receptor Activity
	Biological Process	DNA Repair Base-excision Repair Mismatch Repair Depurination	Apoptotic Process Negative Regulation Of Cell Population Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Population Proliferation
Pathways			TNFs bind their physiological receptors
Drugs			Urelumab
Diseases		Familial adenomatous polyposis
GWAS		Composite immunoglobulin trait (IgA/IgM) ( 28628107) Periventricular white matter hyperintensities ( 32517579)	Blond vs. brown/black hair color ( 30531825) Celiac disease ( 20190752) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Psoriasis ( 25903422 23143594) Rheumatoid arthritis ( 30423114 24390342) Ulcerative colitis ( 28067908 21297633) Waist-hip ratio ( 28552196)
Interacting Genes		19 interacting genes: AGTRAP APEX1 BAAT CYLC2 FANCC HRAS LMNA LRSAM1 MSANTD3 MSH6 PCNA RPA1 RPA4 SEC61B SIRT6 SMAD1 TDRD7 TSTD2 XPA	7 interacting genes: LRR1 SERP1 TNFRSF4 TNFSF9 TRAF1 TRAF2 TRAF3
Entrez ID		4595	3604
HPRD ID		05380	03767
Ensembl ID		ENSG00000132781	ENSG00000049249
Uniprot IDs		D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 Q9UIF7	Q07011
PDB IDs		1X51 3N5N	6A3V 6A3W 6BWV 6CPR 6CU0 6MGP 6MHR 6MI2
Enriched GO Terms of Interacting Partners?
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