MTIF2 and NFKBIB

Data Source:
HPRD (in vitro)

		MTIF2	NFKBIB
Description		mitochondrial translational initiation factor 2	NFKB inhibitor beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion	Nucleus Cytosol
	Molecular Function	RNA Binding Translation Initiation Factor Activity GTPase Activity GTP Binding Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Regulation Of Translational Initiation Ribosome Disassembly Mitochondrial Translational Initiation	Transcription, DNA-templated Signal Transduction Cytoplasmic Sequestering Of NF-kappaB Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide
Pathways		Mitochondrial translation initiation	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS		Dementia and core Alzheimer's disease neuropathologic changes ( 25188341)
Interacting Genes		3 interacting genes: HSPB1 NFKBIB TSC22D2	43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52
Entrez ID		4528	4793
HPRD ID		04792	07260
Ensembl ID		ENSG00000085760	ENSG00000104825
Uniprot IDs		P46199 Q6P1N2	G5E9C2 Q15653
PDB IDs		6GAW 6GAZ 6GB2 6RW5
Enriched GO Terms of Interacting Partners?
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