NFKBIB and NKIRAS1

Data Source:
HPRD (in vitro, in vivo)

		NFKBIB	NKIRAS1
Description		NFKB inhibitor beta	NFKB inhibitor interacting Ras like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Cellular_component Endoplasmic Reticulum Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding	GTPase Activity GTP Binding
	Biological Process	Transcription, DNA-templated Signal Transduction Cytoplasmic Sequestering Of NF-kappaB Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide	I-kappaB Kinase/NF-kappaB Signaling
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation	RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435)
Interacting Genes		43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	8 interacting genes: ACVR1 APP BMPR1B NFKBIA NFKBIB SMURF2 TGFBR1 XRCC2
Entrez ID		4793	28512
HPRD ID		07260	06841
Ensembl ID		ENSG00000104825	ENSG00000197885
Uniprot IDs		G5E9C2 Q15653	Q9NYS0
PDB IDs
Enriched GO Terms of Interacting Partners?
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