NFKBIB and RASAL2

Data Source:
HPRD (in vitro)

		NFKBIB	RASAL2
Description		NFKB inhibitor beta	RAS protein activator like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Transcription, DNA-templated Signal Transduction Cytoplasmic Sequestering Of NF-kappaB Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide	MAPK Cascade Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation	Regulation of RAS by GAPs
Drugs
Diseases
GWAS			Bipolar disorder ( 28115744) Body mass index ( 26426971 19079260) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Immune response to smallpox vaccine (IL-6) ( 22542470) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Weight ( 19079260)
Interacting Genes		43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	8 interacting genes: MCC MEOX2 MIA2 NFKBIB TRAF1 UBC USHBP1 YWHAG
Entrez ID		4793	9462
HPRD ID		07260	05845
Ensembl ID		ENSG00000104825	ENSG00000075391
Uniprot IDs		G5E9C2 Q15653	A8K2P3 Q9UJF2
PDB IDs
Enriched GO Terms of Interacting Partners?
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