ASGR1 and NLK

Data Source:
BioGRID (two hybrid)

		ASGR1	NLK
Description		asialoglycoprotein receptor 1	nemo like kinase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Metal Ion Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding SH2 Domain Binding
	Biological Process	Receptor-mediated Endocytosis Viral Process Protein N-linked Glycosylation Via Asparagine Cellular Response To Extracellular Stimulus	MAPK Cascade Regulation Of Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Intracellular Signal Transduction Serine Phosphorylation Of STAT Protein Protein Autophosphorylation Protein Stabilization
Pathways		Asparagine N-linked glycosylation	Ca2+ pathway
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Medication use (HMG CoA reductase inhibitors) ( 31015401) Serum alkaline phosphatase levels ( 31666285 29403010)	Non-response to bupropion and depression ( 27622933)
Interacting Genes		43 interacting genes: AHNAK2 AMIGO1 APH1A APP ASGR2 ATP1B4 BLCAP CERS2 CLDN7 CLEC4G CPLX4 CREB3L1 CYB5R3 DHFR ERGIC3 FAM209A FCGR1A FNDC9 GPX8 HIBADH HIVEP1 HSP90AA1 HSP90B1 IGFBP5 KIR2DL3 LAMTOR5 LEUTX LMNA MCEMP1 NEMP1 NLK PDZK1IP1 RBBP6 RNF19B SAR1A SLC10A1 SLC35C2 SPAG4 SUSD3 TG TMX2 VKORC1 VSIR	25 interacting genes: ASGR1 ATXN1 CREBBP CUL1 FBXW5 FOXO4 FOXP3 GRN HIPK2 KRTAP10-1 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 NDOR1 QRICH1 RCHY1 SDR16C5 SKP2 STAT3 USP4 ZHX3
Entrez ID		432	51701
HPRD ID		00151	17637
Ensembl ID		ENSG00000141505	ENSG00000087095
Uniprot IDs		P07306 Q6FGQ5	A0A024QZ12 Q9UBE8
PDB IDs		1DV8 5JPV 5JQ1
Enriched GO Terms of Interacting Partners?
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