ASGR1 and RNF19B

Data Source:
BioGRID (two hybrid)

		ASGR1	RNF19B
Description		asialoglycoprotein receptor 1	ring finger protein 19B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Cytolytic Granule
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Metal Ion Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Receptor-mediated Endocytosis Viral Process Protein N-linked Glycosylation Via Asparagine Cellular Response To Extracellular Stimulus	Protein Polyubiquitination Adaptive Immune Response Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Natural Killer Cell Mediated Cytotoxicity Protein Autoubiquitination
Pathways		Asparagine N-linked glycosylation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Medication use (HMG CoA reductase inhibitors) ( 31015401) Serum alkaline phosphatase levels ( 31666285 29403010)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		43 interacting genes: AHNAK2 AMIGO1 APH1A APP ASGR2 ATP1B4 BLCAP CERS2 CLDN7 CLEC4G CPLX4 CREB3L1 CYB5R3 DHFR ERGIC3 FAM209A FCGR1A FNDC9 GPX8 HIBADH HIVEP1 HSP90AA1 HSP90B1 IGFBP5 KIR2DL3 LAMTOR5 LEUTX LMNA MCEMP1 NEMP1 NLK PDZK1IP1 RBBP6 RNF19B SAR1A SLC10A1 SLC35C2 SPAG4 SUSD3 TG TMX2 VKORC1 VSIR	31 interacting genes: AP1M1 APOL3 ASGR1 CDIPT CLEC1A DHODH FDPS GIMAP5 GOSR2 ICMT MEST MFSD5 MS4A1 NIPAL4 PPP1CC RAP1GDS1 SACM1L SEC22A SEC23A SELENOK SLC30A3 TAP1 TMEM100 TMEM120B TMEM208 TMEM31 TNF TSPAN2 UBE2D2 UBE2D3 UBE2L3
Entrez ID		432	127544
HPRD ID		00151	13725
Ensembl ID		ENSG00000141505	ENSG00000116514
Uniprot IDs		P07306 Q6FGQ5	Q6ZMZ0
PDB IDs		1DV8 5JPV 5JQ1
Enriched GO Terms of Interacting Partners?
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