MKI67 and CBX3

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid, in vitro)

		MKI67	CBX3
Description		marker of proliferation Ki-67	chromobox 3
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Membrane Nuclear Body	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage
	Molecular Function	DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding	Protein Binding Transcription Factor Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Cell Cycle Regulation Of Mitotic Nuclear Division Cell Population Proliferation Regulation Of Chromosome Segregation Regulation Of Chromatin Organization	Chromatin Remodeling Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of G0 To G1 Transition Cellular Response To Dexamethasone Stimulus
Pathways			ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Drug experimentation measurement ( 30718321) Lead levels ( 26025379) Select biomarker traits ( 17903293) Triglyceride levels x loop diuretics use interaction ( 31806883)	Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: CBX3 CBX5 CDK1 ECPAS HINFP KIF15 NIFK PRKCB PTEN SMN1 SUMO2 TK1 TRIM55 TRIM63	46 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LRIF1 MGA MIS12 MKI67 MRPL12 NSD3 NSL1 PIM1 PRR14 RAD54L2 SP100 STK16 SUV39H1 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280C ZNF280D ZNF496
Entrez ID		4288	11335
HPRD ID		08902	05130
Ensembl ID		ENSG00000148773	ENSG00000122565
Uniprot IDs		P46013	A4D177 Q13185
PDB IDs		1R21 2AFF 5J28	2L11 3DM1 3KUP 3TZD 5T1I 6HW2
Enriched GO Terms of Interacting Partners?
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