CBX3 and ZNF280D

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		CBX3	ZNF280D
Description		chromobox 3	zinc finger protein 280D
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage	Nucleus
	Molecular Function	Protein Binding Transcription Factor Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Chromatin Remodeling Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of G0 To G1 Transition Cellular Response To Dexamethasone Stimulus	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body fat mass ( 28552196) Glaucoma (primary open-angle) ( 29891935) Hand grip strength ( 29691431) Intraocular pressure ( 29785010 31959993 30054594) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Triglyceride levels ( 32203549)
Interacting Genes		46 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LRIF1 MGA MIS12 MKI67 MRPL12 NSD3 NSL1 PIM1 PRR14 RAD54L2 SP100 STK16 SUV39H1 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280C ZNF280D ZNF496	3 interacting genes: BRCA1 CBX3 CBX5
Entrez ID		11335	54816
HPRD ID		05130	15448
Ensembl ID		ENSG00000122565	ENSG00000137871
Uniprot IDs		A4D177 Q13185	H0YL38 Q6N043
PDB IDs		2L11 3DM1 3KUP 3TZD 5T1I 6HW2
Enriched GO Terms of Interacting Partners?
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