MAP3K4 and DIXDC1

Data Source:
HPRD (in vivo, in vitro)

		MAP3K4	DIXDC1
Description		mitogen-activated protein kinase kinase kinase 4	DIX domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Actin Binding Protein Binding Protein Domain Specific Binding Gamma-tubulin Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Response To UV-C Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping	Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Wnt Signaling Pathway Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Differentiation Canonical Wnt Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	8 interacting genes: APP ATXN1 AXIN1 CDC5L MAP3K4 NDEL1 ULK2 ZDHHC17
Entrez ID		4216	85458
HPRD ID		03886	16804
Ensembl ID		ENSG00000085511	ENSG00000150764
Uniprot IDs		Q9P1M2 Q9Y6R4	Q155Q3
PDB IDs			3PZ7
Enriched GO Terms of Interacting Partners?
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