MAP3K4 and MAP2K3

Data Source:
BioGRID (imaging technique)
HPRD (in vitro, in vivo)

		MAP3K4	MAP2K3
Description		mitogen-activated protein kinase kinase kinase 4	mitogen-activated protein kinase kinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Nucleoplasm Cytosol Membrane
	Molecular Function	MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Response To UV-C Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping	Activation Of MAPK Activity Regulation Of Cytokine Production Inflammatory Response Signal Transduction Peptidyl-tyrosine Phosphorylation Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction
Pathways			Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)	Body mass index ( 26426971 28892062)
Interacting Genes		26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	54 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53
Entrez ID		4216	5606
HPRD ID		03886	03816
Ensembl ID		ENSG00000085511	ENSG00000034152
Uniprot IDs		Q9P1M2 Q9Y6R4	P46734 Q6FI23
PDB IDs
Enriched GO Terms of Interacting Partners?
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