MAP3K4 and CNTRL

Data Source:
BioGRID (two hybrid)

		MAP3K4	CNTRL
Description		mitogen-activated protein kinase kinase kinase 4	centriolin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Centrosome Microtubule Organizing Center Cytosol Membrane Perinuclear Region Of Cytoplasm Flemming Body Meiotic Spindle Pole Mitotic Spindle Pole Centriolar Subdistal Appendage
	Molecular Function	MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding Cytoskeletal Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Response To UV-C Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping	G2/M Transition Of Mitotic Cell Cycle Kidney Development Ventricular Septum Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Aorta Development Cell Division Regulation Of Cytoskeleton Organization Coronary Vasculature Development Ciliary Basal Body-plasma Membrane Docking
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Fostamatinib
Diseases
GWAS		Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)	Pulse pressure ( 27841878)
Interacting Genes		26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	3 interacting genes: MAP3K4 MAPK6 TRADD
Entrez ID		4216	11064
HPRD ID		03886	05691
Ensembl ID		ENSG00000085511	ENSG00000119397
Uniprot IDs		Q9P1M2 Q9Y6R4	B2RP65 Q7Z7A1
PDB IDs
Enriched GO Terms of Interacting Partners?
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