MBL2 and MASP2

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MBL2	MASP2
Description		mannose binding lectin 2	MBL associated serine protease 2
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cell Surface Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Mannose Binding Calcium-dependent Protein Binding	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Innate Immune Response Negative Regulation Of Viral Process Defense Response To Gram-positive Bacterium	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway
Pathways		Lectin pathway of complement activation Initial triggering of complement
Drugs		O3-Sulfonylgalactose Methyl alpha-D-mannoside 4-(Hydrogen sulfate)-beta-D-galactopyranose Methyl beta-L-fucopyranoside N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine	beta-Hydroxyasparagine
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency Tuberculosis	Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576 29875488 28240269) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)	Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)
Interacting Genes		9 interacting genes: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC UBQLN2	4 interacting genes: C4A FCN2 MBL2 SERPING1
Entrez ID		4153	10747
HPRD ID		01107	05484
Ensembl ID		ENSG00000165471	ENSG00000009724
Uniprot IDs		P11226	O00187
PDB IDs		1HUP	1Q3X 1SZB 1ZJK 3TVJ 4FXG 5JPM
Enriched GO Terms of Interacting Partners?
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