MASP2 and MBL2

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MASP2	MBL2
Description		MBL associated serine protease 2	mannose binding lectin 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Collagen Trimer Extracellular Space Cell Surface Collagen-containing Extracellular Matrix
	Molecular Function	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding	Signaling Receptor Binding Protein Binding Mannose Binding Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway	Complement Activation, Lectin Pathway Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Innate Immune Response Negative Regulation Of Viral Process Defense Response To Gram-positive Bacterium
Pathways			Lectin pathway of complement activation Initial triggering of complement
Drugs		beta-Hydroxyasparagine	O3-Sulfonylgalactose Methyl alpha-D-mannoside 4-(Hydrogen sulfate)-beta-D-galactopyranose Methyl beta-L-fucopyranoside N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency	Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency Tuberculosis
GWAS		Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)	Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576 29875488 28240269) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)
Interacting Genes		4 interacting genes: C4A FCN2 MBL2 SERPING1	9 interacting genes: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC UBQLN2
Entrez ID		10747	4153
HPRD ID		05484	01107
Ensembl ID		ENSG00000009724	ENSG00000165471
Uniprot IDs		O00187	P11226
PDB IDs		1Q3X 1SZB 1ZJK 3TVJ 4FXG 5JPM	1HUP
Enriched GO Terms of Interacting Partners?
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