MBL2 and CD93

Data Source:
HPRD (in vitro)

		MBL2	CD93
Description		mannose binding lectin 2	CD93 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cell Surface Collagen-containing Extracellular Matrix	Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Mannose Binding Calcium-dependent Protein Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Complement Activation, Lectin Pathway Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Innate Immune Response Negative Regulation Of Viral Process Defense Response To Gram-positive Bacterium	Phagocytosis Viral Process Macrophage Activation Neutrophil Degranulation Cell-cell Adhesion
Pathways		Lectin pathway of complement activation Initial triggering of complement	Neutrophil degranulation
Drugs		O3-Sulfonylgalactose Methyl alpha-D-mannoside 4-(Hydrogen sulfate)-beta-D-galactopyranose Methyl beta-L-fucopyranoside N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency Tuberculosis
GWAS		Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576 29875488 28240269) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)	Liver enzyme levels (alanine transaminase) ( 24124411) Obesity-related traits ( 23251661) Venous thromboembolism ( 26888256 31676865)
Interacting Genes		9 interacting genes: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC UBQLN2	23 interacting genes: ARHGAP15 BAG6 C1QA COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COPS5 F12 GIPC1 KIR2DL2 KNG1 MBL2 MSN MYD88 RANBP1 SCYL1 TENT5A UBQLN2
Entrez ID		4153	22918
HPRD ID		01107	00396
Ensembl ID		ENSG00000165471	ENSG00000125810
Uniprot IDs		P11226	Q9NPY3
PDB IDs		1HUP
Enriched GO Terms of Interacting Partners?
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