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LIG4 and TPT1
Data Source:
BioGRID
(two hybrid)
LIG4
TPT1
Description
DNA ligase 4
tumor protein, translationally-controlled 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Cytoplasmic Ribonucleoprotein Granule
Nonhomologous End Joining Complex
Spindle Pole
Extracellular Space
Nucleus
Cytoplasm
Multivesicular Body
Cytosol
Cytoplasmic Microtubule
Extracellular Exosome
Molecular Function
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Ligase Activity
Metal Ion Binding
RNA Binding
Calcium Ion Binding
Protein Binding
Biological Process
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Replication
DNA Ligation
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Cycle
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Gamma Radiation
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
DNA Ligation Involved In DNA Recombination
DNA Ligation Involved In DNA Repair
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Chromosome Organization
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Response To Virus
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
Drugs
Calcium citrate
Calcium Phosphate
Calcium phosphate dihydrate
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Type 2 diabetes (
25760438
)
Interacting Genes
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FAM214A
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
30 interacting genes:
APP
ATP1A1
ATP1A2
BCL2L1
CALM1
DBN1
EEF1A1
EEF1A2
EEF1B2
EEF1D
FANCA
HSPB1
IKBKG
LIG4
MCL1
MCPH1
MDM2
MLC1
NKX3-1
NOTCH3
PER2
PLK1
RBBP6
RPLP1
SNX6
SPP1
STEAP3
TRIP13
TUBB2A
VHL
Entrez ID
3981
7178
HPRD ID
03500
15979
Ensembl ID
ENSG00000174405
ENSG00000133112
Uniprot IDs
A0A024RE06
A0A0C4DGV9
A8K8Q4
P49917
A0A024RDY2
A0A0B4J2C3
A0A0P1J1R0
P13693
PDB IDs
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
1YZ1
2HR9
3EBM
4Z9V
5O9L
5O9M
6IZB
6IZE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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