LALBA and B4GALT1

Data Source:
HPRD (in vitro)

		LALBA	B4GALT1
Description		lactalbumin alpha	beta-1,4-galactosyltransferase 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Golgi Lumen	Golgi Trans Cisterna Golgi Membrane Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Desmosome Filopodium Secretory Granule Membrane Brush Border Membrane Golgi Cisterna Membrane Azurophil Granule Membrane Extracellular Exosome
	Molecular Function	Lactose Synthase Activity Calcium Ion Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Cytoskeletal Protein Binding Galactosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity
	Biological Process	Lactose Biosynthetic Process Apoptotic Process Signal Transduction Cell-cell Signaling Defense Response To Bacterium	Epithelial Cell Development Acute Inflammatory Response Lactose Biosynthetic Process Galactose Metabolic Process Protein N-linked Glycosylation Cell Adhesion Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Negative Regulation Of Cell Population Proliferation Oligosaccharide Biosynthetic Process Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process Neutrophil Degranulation Development Of Secondary Sexual Characteristics Leukocyte Migration Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Glycosylation
Pathways		Lactose synthesis	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Interaction With Cumulus Cells And The Zona Pellucida Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Lactose synthesis Neutrophil degranulation N-Glycan antennae elongation
Drugs		Palmitic Acid	N-Acetylglucosamine 6-Aminohexyl-uridine-C1,5'-diphosphate 4)-N-acetyl-beta-D-glucosamine Galactose-uridine-5'-diphosphate Uridine monophosphate 2-(N-morpholino)ethanesulfonic acid
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Adiponectin levels ( 24105470) Itch intensity from mosquito bite adjusted by bite size ( 28199695)	Aspartate aminotransferase levels ( 29403010) Blood protein levels ( 30072576 29875488) Hematocrit ( 32888494) Hemoglobin ( 32888494) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) Influenza A (H1N1) infection ( 26379185) Mild influenza (H1N1) infection ( 26379185) N-glycan levels ( 31163085) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Severe influenza A (H1N1) infection ( 26379185) Urate levels ( 31985003 31578528 23263486)
Interacting Genes		6 interacting genes: B4GALT1 CRYAA CRYAB H2BC21 H3C15 HSPA8	8 interacting genes: CDK11A EGFR LALBA OR10G4 TFRC TUBA1A TUBA4A TUBB
Entrez ID		3906	2683
HPRD ID		01024	00659
Ensembl ID		ENSG00000167531	ENSG00000086062
Uniprot IDs		A0A080YV01 P00709	P15291
PDB IDs		1A4V 1B9O 1CB3 1HML 3B0I 3B0O 4L41	2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41 6FWT 6FWU
Enriched GO Terms of Interacting Partners?
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