B4GALT1 and TUBA4A

Data Source:
HPRD (in vivo)

		B4GALT1	TUBA4A
Description		beta-1,4-galactosyltransferase 1	tubulin alpha 4a
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Desmosome Filopodium Secretory Granule Membrane Brush Border Membrane Golgi Cisterna Membrane Azurophil Granule Membrane Extracellular Exosome	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Extracellular Exosome
	Molecular Function	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Cytoskeletal Protein Binding Galactosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Epithelial Cell Development Acute Inflammatory Response Lactose Biosynthetic Process Galactose Metabolic Process Protein N-linked Glycosylation Cell Adhesion Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Negative Regulation Of Cell Population Proliferation Oligosaccharide Biosynthetic Process Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process Neutrophil Degranulation Development Of Secondary Sexual Characteristics Leukocyte Migration Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Glycosylation	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Platelet Degranulation Regulation Of G2/M Transition Of Mitotic Cell Cycle Ciliary Basal Body-plasma Membrane Docking
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Interaction With Cumulus Cells And The Zona Pellucida Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Lactose synthesis Neutrophil degranulation N-Glycan antennae elongation	Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		N-Acetylglucosamine 6-Aminohexyl-uridine-C1,5'-diphosphate 4)-N-acetyl-beta-D-glucosamine Galactose-uridine-5'-diphosphate Uridine monophosphate 2-(N-morpholino)ethanesulfonic acid	Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate
Diseases		Congenital disorders of glycosylation (CDG) type II
GWAS		Aspartate aminotransferase levels ( 29403010) Blood protein levels ( 30072576 29875488) Hematocrit ( 32888494) Hemoglobin ( 32888494) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) Influenza A (H1N1) infection ( 26379185) Mild influenza (H1N1) infection ( 26379185) N-glycan levels ( 31163085) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Severe influenza A (H1N1) infection ( 26379185) Urate levels ( 31985003 31578528 23263486)	Platelet distribution width ( 32888494 27863252)
Interacting Genes		8 interacting genes: CDK11A EGFR LALBA OR10G4 TFRC TUBA1A TUBA4A TUBB	51 interacting genes: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UCHL5 VAV1 VDAC1 YWHAG ZAP70
Entrez ID		2683	7277
HPRD ID		00659	01851
Ensembl ID		ENSG00000086062	ENSG00000127824
Uniprot IDs		P15291	P68366
PDB IDs		2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41 6FWT 6FWU
Enriched GO Terms of Interacting Partners?
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