KPNB1 and PTN

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KPNB1	PTN
Description		karyopherin subunit beta 1	pleiotrophin
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Membrane Specific Granule Lumen Host Cell Extracellular Exosome Endoplasmic Reticulum Tubular Network Ficolin-1-rich Granule Lumen	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Surface Neuromuscular Junction Protein-containing Complex Perinuclear Region Of Cytoplasm Presynapse Postsynapse
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Nuclear Import Signal Receptor Activity	Protein Phosphatase Inhibitor Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Protein Kinase Binding Chondroitin Sulfate Proteoglycan Binding Chondroitin Sulfate Binding Vascular Endothelial Growth Factor Binding Syndecan Binding Heparan Sulfate Binding
	Biological Process	Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Modulation By Virus Of Host Cellular Process Astral Microtubule Organization Ran Protein Signal Transduction Establishment Of Mitotic Spindle Localization Neutrophil Degranulation Establishment Of Protein Localization Regulation Of Cholesterol Biosynthetic Process Intracellular Transport Of Virus Mitotic Spindle Assembly	Liver Development Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Heart Development Learning Memory Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Response To Activity Negative Regulation Of Angiogenesis Spinal Cord Development Cerebellum Development Thalamus Development Bone Mineralization Lung Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Dendrite Regeneration Regulation Of Myelination Response To Estradiol Negative Regulation Of Phosphoprotein Phosphatase Activity Response To Progesterone Cellular Response To UV Cellular Response To Platelet-derived Growth Factor Stimulus Tissue Regeneration Response To Drug Positive Regulation Of Apoptotic Process Receptor Clustering Ossification Involved In Bone Remodeling Estrous Cycle Endothelial Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Membrane Potential Decidualization Regulation Of Synaptic Plasticity Oogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Retinal Rod Cell Differentiation Negative Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Cellular Response To Vitamin D Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Proliferation Dendrite Arborization Positive Regulation Of Dendrite Development Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Hemopoiesis Response To Kainic Acid Rod Bipolar Cell Differentiation Response To Ciliary Neurotrophic Factor Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Neuromuscular Junction Development Response To Nerve Growth Factor Regulation Of Stem Cell Population Maintenance Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Stem Cell Differentiation
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Postmitotic nuclear pore complex (NPC) reformation Inhibition of nitric oxide production
Drugs
Diseases
GWAS		Asthma ( 31619474) Body mass index ( 26426971) Glycine levels ( 30837465) HDL cholesterol ( 30275531) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 22190364) Optic cup area ( 25631615) Simvastatin-induced myopathy ( 31220337) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Aluminium levels ( 26025379) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 25056061 29483656)
Interacting Genes		68 interacting genes: AMFR CD99 CHD3 CRBN CSE1L CSNK1A1 CUL4A CUL4B ELAVL1 EPAS1 EXO1 FGFR1 H1-0 H1-2 IGFBP3 IGFBP5 IPO7 IPO8 ITCH KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LINC01554 LYST MESD MSL1 MTNR1A NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTEN PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RBX1 RPL5 RUNX1T1 SELENOS SENP2 SMAD2 SMAD3 SMN1 SMNDC1 SNAPIN SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5	98 interacting genes: ACTB ALK APOBEC3G ARIH2 ARL15 ASPH ATP5F1C ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GPD1 GPRASP2 GSDME GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RACK1 RBM23 RIT1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WASHC3 WFDC2
Entrez ID		3837	5764
HPRD ID		04114	01199
Ensembl ID		ENSG00000108424	ENSG00000105894
Uniprot IDs		B7Z752 Q14974	A0A024R778 P21246
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW 3W5K 6N88 6N89	2N6F
Enriched GO Terms of Interacting Partners?
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