PTN and TOMM20

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTN	TOMM20
Description		pleiotrophin	translocase of outer mitochondrial membrane 20
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Surface Neuromuscular Junction Protein-containing Complex Perinuclear Region Of Cytoplasm Presynapse Postsynapse	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Integral Component Of Mitochondrial Outer Membrane Mitochondria-associated Endoplasmic Reticulum Membrane
	Molecular Function	Protein Phosphatase Inhibitor Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Protein Kinase Binding Chondroitin Sulfate Proteoglycan Binding Chondroitin Sulfate Binding Vascular Endothelial Growth Factor Binding Syndecan Binding Heparan Sulfate Binding	Protein Binding Protein Transmembrane Transporter Activity P-P-bond-hydrolysis-driven Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Unfolded Protein Binding
	Biological Process	Liver Development Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Heart Development Learning Memory Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Response To Activity Negative Regulation Of Angiogenesis Spinal Cord Development Cerebellum Development Thalamus Development Bone Mineralization Lung Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Dendrite Regeneration Regulation Of Myelination Response To Estradiol Negative Regulation Of Phosphoprotein Phosphatase Activity Response To Progesterone Cellular Response To UV Cellular Response To Platelet-derived Growth Factor Stimulus Tissue Regeneration Response To Drug Positive Regulation Of Apoptotic Process Receptor Clustering Ossification Involved In Bone Remodeling Estrous Cycle Endothelial Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Membrane Potential Decidualization Regulation Of Synaptic Plasticity Oogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Retinal Rod Cell Differentiation Negative Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Cellular Response To Vitamin D Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Proliferation Dendrite Arborization Positive Regulation Of Dendrite Development Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Hemopoiesis Response To Kainic Acid Rod Bipolar Cell Differentiation Response To Ciliary Neurotrophic Factor Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Neuromuscular Junction Development Response To Nerve Growth Factor Regulation Of Stem Cell Population Maintenance Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Stem Cell Differentiation	Protein Targeting To Mitochondrion Response To Muscle Activity TRNA Import Into Mitochondrion Macroautophagy Protein Deubiquitination Protein Import Into Mitochondrial Matrix Response To 3,3',5-triiodo-L-thyronine
Pathways			Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases
Drugs
Diseases
GWAS		Aluminium levels ( 26025379) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 25056061 29483656)	Apolipoprotein A1 levels ( 32203549) Cholesterol, total ( 20686565) Cobalt levels ( 26025379) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661)
Interacting Genes		98 interacting genes: ACTB ALK APOBEC3G ARIH2 ARL15 ASPH ATP5F1C ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GPD1 GPRASP2 GSDME GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RACK1 RBM23 RIT1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WASHC3 WFDC2	19 interacting genes: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 CEP126 DHFR FBXO7 FEZ1 HAP1 HSD17B10 OTC PPHLN1 PTN TOMM22 TOMM40 UCP1 VDAC1
Entrez ID		5764	9804
HPRD ID		01199	03507
Ensembl ID		ENSG00000105894	ENSG00000173726
Uniprot IDs		A0A024R778 P21246	A0A024R3W2 Q15388
PDB IDs		2N6F	4APO
Enriched GO Terms of Interacting Partners?
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