KPNB1 and SMNDC1

Data Source:
HPRD (in vitro)

		KPNB1	SMNDC1
Description		karyopherin subunit beta 1	survival motor neuron domain containing 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Membrane Specific Granule Lumen Host Cell Extracellular Exosome Endoplasmic Reticulum Tubular Network Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Nuclear Speck
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Nuclear Import Signal Receptor Activity	RNA Binding Protein Binding
	Biological Process	Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Modulation By Virus Of Host Cellular Process Astral Microtubule Organization Ran Protein Signal Transduction Establishment Of Mitotic Spindle Localization Neutrophil Degranulation Establishment Of Protein Localization Regulation Of Cholesterol Biosynthetic Process Intracellular Transport Of Virus Mitotic Spindle Assembly	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Apoptotic Process
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Postmitotic nuclear pore complex (NPC) reformation Inhibition of nitric oxide production	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Asthma ( 31619474) Body mass index ( 26426971) Glycine levels ( 30837465) HDL cholesterol ( 30275531) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 22190364) Optic cup area ( 25631615) Simvastatin-induced myopathy ( 31220337) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Crohn's disease ( 23850713) Refractive error ( 32231278)
Interacting Genes		68 interacting genes: AMFR CD99 CHD3 CRBN CSE1L CSNK1A1 CUL4A CUL4B ELAVL1 EPAS1 EXO1 FGFR1 H1-0 H1-2 IGFBP3 IGFBP5 IPO7 IPO8 ITCH KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LINC01554 LYST MESD MSL1 MTNR1A NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTEN PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RBX1 RPL5 RUNX1T1 SELENOS SENP2 SMAD2 SMAD3 SMN1 SMNDC1 SNAPIN SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5	4 interacting genes: H3-4 KPNB1 SNRNP200 SNRPB
Entrez ID		3837	10285
HPRD ID		04114	04627
Ensembl ID		ENSG00000108424	ENSG00000119953
Uniprot IDs		B7Z752 Q14974	O75940
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW 3W5K 6N88 6N89	4A4F 4A4H
Enriched GO Terms of Interacting Partners?
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