KCND2 and NCS1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KCND2	NCS1
Description		potassium voltage-gated channel subfamily D member 2	neuronal calcium sensor 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Postsynaptic Density Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Neuronal Cell Body Membrane Dendritic Spine Perikaryon Plasma Membrane Raft Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane	Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Dendrite Dense Core Granule Intracellular Membrane-bounded Organelle Calyx Of Held Perinuclear Region Of Cytoplasm Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Protein Binding Metal Ion Binding Voltage-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Action Potential Chemical Synaptic Transmission Neuronal Action Potential Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Locomotor Rhythm Protein Homooligomerization Regulation Of Postsynaptic Membrane Potential Cardiac Conduction Cellular Response To Hypoxia Potassium Ion Transmembrane Transport	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways		Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels
Drugs		Enflurane Disopyramide Imipramine Promethazine Miconazole Dalfampridine	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Alcohol and nicotine co-dependence ( 22488850) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969)	Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)
Interacting Genes		8 interacting genes: DLG4 DPP10 FLNC IL16 KCNIP1 KCNIP2 KCNIP4 NCS1	27 interacting genes: C1QTNF2 CDSN CEP89 CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10
Entrez ID		3751	23413
HPRD ID		09254	04500
Ensembl ID		ENSG00000184408	ENSG00000107130
Uniprot IDs		A4D0V9 Q9NZV8	A0A024R8B2 P62166
PDB IDs			1G8I 2LCP 4GUK 5O9S 6QI4
Enriched GO Terms of Interacting Partners?
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