KCND2 and DPP10

Data Source:
BioGRID (affinity chromatography technology, pull down)

		KCND2	DPP10
Description		potassium voltage-gated channel subfamily D member 2	dipeptidyl peptidase like 10
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Postsynaptic Density Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Neuronal Cell Body Membrane Dendritic Spine Perikaryon Plasma Membrane Raft Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Protein Binding Metal Ion Binding Voltage-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Potassium Channel Regulator Activity Ion Channel Binding
	Biological Process	Action Potential Chemical Synaptic Transmission Neuronal Action Potential Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Locomotor Rhythm Protein Homooligomerization Regulation Of Postsynaptic Membrane Potential Cardiac Conduction Cellular Response To Hypoxia Potassium Ion Transmembrane Transport	Proteolysis Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels
Drugs		Enflurane Disopyramide Imipramine Promethazine Miconazole Dalfampridine
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Alcohol and nicotine co-dependence ( 22488850) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adverse response to drug ( 30420678) Cadmium levels ( 26025379) Daytime sleep phenotypes ( 27126917) High chromosomal aberration frequency (chromatid type) in genotoxic compound exposure ( 31586183) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Neuritic plaque ( 31497858) Obesity-related traits ( 23251661) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Plasma parathyroid hormone levels ( 30134803) Pulmonary function (FVC) x omega-3 PUFA (docosahexaenoic acid) interaction (2df) ( 30199657) Response to antidepressants in depression ( 27622933) Severe influenza A (H1N1) infection ( 26379185) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Suicide attempts in major depressive disorder ( 26079190) Survival in colon cancer ( 25866641) Survival in microsatellite instability low/stable colorectal cancer ( 25866641) Systolic blood pressure in sickle cell anemia ( 24058526) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		8 interacting genes: DLG4 DPP10 FLNC IL16 KCNIP1 KCNIP2 KCNIP4 NCS1	1 interacting genes: KCND2
Entrez ID		3751	57628
HPRD ID		09254	07083
Ensembl ID		ENSG00000184408	ENSG00000175497
Uniprot IDs		A4D0V9 Q9NZV8	B2RCJ8 B4DKB5 Q0GLB7 Q0GLB9 Q8N608
PDB IDs			4WJL
Enriched GO Terms of Interacting Partners?
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