NCS1 and CEP89

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		NCS1	CEP89
Description		neuronal calcium sensor 1	centrosomal protein 89
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Dendrite Dense Core Granule Intracellular Membrane-bounded Organelle Calyx Of Held Perinuclear Region Of Cytoplasm Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Spindle Pole Mitochondrial Intermembrane Space Centrosome Centriole Cytosol Plasma Membrane Motile Cilium Synapse Ciliary Transition Fiber Non-motile Cilium
	Molecular Function	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels	Protein Binding
	Biological Process	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis	Mitochondrion Organization Chemical Synaptic Transmission Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Non-motile Cilium Assembly
Pathways			Anchoring of the basal body to the plasma membrane
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)	Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Longevity (age >90th survival percentile) ( 31413261) Urate levels ( 31578528)
Interacting Genes		27 interacting genes: C1QTNF2 CDSN CEP89 CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10	2 interacting genes: NCS1 PICK1
Entrez ID		23413	84902
HPRD ID		04500	08601
Ensembl ID		ENSG00000107130	ENSG00000121289
Uniprot IDs		A0A024R8B2 P62166	Q96ST8
PDB IDs		1G8I 2LCP 4GUK 5O9S 6QI4
Enriched GO Terms of Interacting Partners?
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