ITGA4 and LPXN

Data Source:
HPRD (in vivo)

		ITGA4	LPXN
Description		integrin subunit alpha 4	leupaxin
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Growth Cone Integrin Alpha4-beta1 Complex Integrin Alpha4-beta7 Complex Neuronal Cell Body Extracellular Exosome	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Fibronectin Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Metal Ion Binding Cell Adhesion Molecule Binding Protein Antigen Binding	Transcription Coregulator Activity Protein Binding Metal Ion Binding
	Biological Process	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway B Cell Differentiation Extracellular Matrix Organization Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Diapedesis Axonogenesis Involved In Innervation Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Homodimerization Activity Import Into Cell Cell-cell Adhesion In Response To Extracellular Stimulus Positive Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Amyloid-beta Positive Regulation Of Vascular Endothelial Cell Proliferation Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration	Regulation Of Transcription, DNA-templated Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration Potential therapeutics for SARS
Drugs		Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab MK-0668
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Monocyte count ( 23314186 28193307 25096241 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Monocyte-lymphocyte ratio ( 28193307) Multiple sclerosis ( 24076602) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sweet taste preference ( 32572145) Ulcerative colitis ( 28067908) White blood cell count ( 29403010 32888494 21738480) White blood cell count (basophil) ( 29403010) White blood cell count (monocyte) ( 28158719) White blood cell types ( 21738478)	Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		16 interacting genes: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN	33 interacting genes: AGXT AQP1 GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 LMO3 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RNF214 RUNX1T1 SFI1 TGFB1 TNS2 TXLNB VCL ZNF175 ZNF426
Entrez ID		3676	9404
HPRD ID		01894	05651
Ensembl ID		ENSG00000115232	ENSG00000110031
Uniprot IDs		P13612	B7Z5P7 O60711
PDB IDs		3V4P 3V4V 4HKC 5C7Z 5FPI	1X3H 4XEF 4XEK 4XEV
Enriched GO Terms of Interacting Partners?
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