ITGA4 and TGFB1I1

Data Source:
HPRD (in vitro)

		ITGA4	TGFB1I1
Description		integrin subunit alpha 4	transforming growth factor beta 1 induced transcript 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Growth Cone Integrin Alpha4-beta1 Complex Integrin Alpha4-beta7 Complex Neuronal Cell Body Extracellular Exosome	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Nuclear Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Fibronectin Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Metal Ion Binding Cell Adhesion Molecule Binding Protein Antigen Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Metal Ion Binding Roundabout Binding Androgen Receptor Binding I-SMAD Binding
	Biological Process	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway B Cell Differentiation Extracellular Matrix Organization Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Diapedesis Axonogenesis Involved In Innervation Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Homodimerization Activity Import Into Cell Cell-cell Adhesion In Response To Extracellular Stimulus Positive Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Amyloid-beta Positive Regulation Of Vascular Endothelial Cell Proliferation Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration	Cell Adhesion Negative Regulation Of Cell Population Proliferation Response To Heat Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Epithelial Cell Differentiation Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration Potential therapeutics for SARS
Drugs		Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab MK-0668
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Monocyte count ( 23314186 28193307 25096241 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Monocyte-lymphocyte ratio ( 28193307) Multiple sclerosis ( 24076602) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sweet taste preference ( 32572145) Ulcerative colitis ( 28067908) White blood cell count ( 29403010 32888494 21738480) White blood cell count (basophil) ( 29403010) White blood cell count (monocyte) ( 28158719) White blood cell types ( 21738478)	Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN	29 interacting genes: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HSPB1 ITGA4 MAPK15 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL
Entrez ID		3676	7041
HPRD ID		01894	03831
Ensembl ID		ENSG00000115232	ENSG00000140682
Uniprot IDs		P13612	A0A024QZE7 O43294
PDB IDs		3V4P 3V4V 4HKC 5C7Z 5FPI
Enriched GO Terms of Interacting Partners?
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