INPP5D and XIAP

Data Source:
BioGRID (two hybrid)

		INPP5D	XIAP
Description		inositol polyphosphate-5-phosphatase D	X-linked inhibitor of apoptosis
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Membrane Raft	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity SH3 Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Inositol Phosphate Metabolic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Phosphatidylinositol Dephosphorylation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Leukocyte Migration	Cellular Response To DNA Damage Stimulus Wnt Signaling Pathway Protein Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Neuron Apoptotic Process Regulation Of Cell Cycle Copper Ion Homeostasis Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling	Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Deactivation of the beta-catenin transactivating complex RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Regulation of necroptotic cell death Regulation of PTEN localization Regulation of PTEN stability and activity Regulation of the apoptosome activity
Drugs			1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide Dequalinium N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE AEG35156
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 22412388 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		45 interacting genes: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R CYSRT1 DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1B FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP6-3 LILRB4 LYN MET NOTCH2NLA PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17	92 interacting genes: ACVRL1 AFP AIFM1 AKT1 AKT2 BCL2 BIRC5 BOLA1 BOLA2 BOLA2B BRCA1 CASP10 CASP3 CASP7 CASP9 CCNB1 CDC42 CDK1 CHEK1 CKS1B COMMD1 DIABLO DNM2 DTX3 DYNLL2 ELAVL1 ERCC3 FAF1 GCC1 GOLGA2 GSK3B GSPT1 HNRNPA1 HSPA1A HTRA1 HTRA2 IKBKE INPP5D KCNJ6 LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 MCRS1 MDM2 NEK6 NOD1 NOD2 NOTCH1 NTAQ1 PIBF1 PPIH PPM1K QARS1 RAF1 RFC5 RIPK2 RIPK3 RIPK4 RUNX1T1 SEPTIN4 SERTAD1 SQSTM1 SSX2IP STRADB STUB1 TAB1 TAB2 TBK1 TGFBR1 TLE3 TRAF6 TRIM32 TRIM8 TTC23 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C XAF1
Entrez ID		3635	331
HPRD ID		09033	02094
Ensembl ID		ENSG00000168918	ENSG00000101966
Uniprot IDs		Q92835	B2R9R2 P98170
PDB IDs		2YSX 6IBD 6XY7	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84 5M6E 5M6F 5M6H 5M6L 5M6M 5O6T 5OQW 6EY2 6GJW 6QCI
Enriched GO Terms of Interacting Partners?
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