IL5RA and IL5

Data Source:
HPRD (in vitro, in vivo)

		IL5RA	IL5
Description		interleukin 5 receptor subunit alpha	interleukin 5
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Receptor Activity Interleukin-5 Receptor Activity Protein Binding Cytokine Binding	Cytokine Activity Interleukin-5 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	MAPK Cascade Inflammatory Response To Antigenic Stimulus Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Interleukin-5 Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation	MAPK Cascade Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of B Cell Proliferation Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Podosome Assembly
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Benralizumab	Pranlukast Reslizumab Mepolizumab
Diseases
GWAS		Asthma (childhood onset) ( 22560479) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576 29875488 28240269) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Oleic acid (18:1n-9) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)	Asthma ( 31959851 31619474) Eosinophil counts ( 29403010 19198610 32888494) Inflammatory bowel disease ( 23128233) Pediatric autoimmune diseases ( 26301688) Rosacea symptom severity ( 29771307)
Interacting Genes		7 interacting genes: CSF2RB EGFR IL5 JAK1 JAK2 SDCBP UNC119	1 interacting genes: IL5RA
Entrez ID		3568	3567
HPRD ID		00998	00997
Ensembl ID		ENSG00000091181	ENSG00000113525
Uniprot IDs		A0A024R2E8 Q01344 Q8NHV7	P05113
PDB IDs		1OBX 1OBZ 3QT2 3VA2 6H41	1HUL 3QT2 3VA2
Enriched GO Terms of Interacting Partners?
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