IL5 and IL5RA

Data Source:
HPRD (in vitro, in vivo)

		IL5	IL5RA
Description		interleukin 5	interleukin 5 receptor subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-5 Receptor Binding Protein Binding Growth Factor Activity	Cytokine Receptor Activity Interleukin-5 Receptor Activity Protein Binding Cytokine Binding
	Biological Process	MAPK Cascade Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of B Cell Proliferation Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Podosome Assembly	MAPK Cascade Inflammatory Response To Antigenic Stimulus Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Interleukin-5 Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Pranlukast Reslizumab Mepolizumab	Benralizumab
Diseases
GWAS		Asthma ( 31959851 31619474) Eosinophil counts ( 29403010 19198610 32888494) Inflammatory bowel disease ( 23128233) Pediatric autoimmune diseases ( 26301688) Rosacea symptom severity ( 29771307)	Asthma (childhood onset) ( 22560479) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576 29875488 28240269) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Oleic acid (18:1n-9) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		1 interacting genes: IL5RA	7 interacting genes: CSF2RB EGFR IL5 JAK1 JAK2 SDCBP UNC119
Entrez ID		3567	3568
HPRD ID		00997	00998
Ensembl ID		ENSG00000113525	ENSG00000091181
Uniprot IDs		P05113	A0A024R2E8 Q01344 Q8NHV7
PDB IDs		1HUL 3QT2 3VA2	1OBX 1OBZ 3QT2 3VA2 6H41
Enriched GO Terms of Interacting Partners?
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