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FASLG and TEC
Data Source:
BioGRID
(unspecified method)
FASLG
TEC
Description
Fas ligand
tec protein tyrosine kinase
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Lysosomal Lumen
Perinuclear Region Of Cytoplasm
Cytoplasmic Vesicle Lumen
Extracellular Exosome
Cytosol
Cytoskeleton
Plasma Membrane
Molecular Function
Signaling Receptor Binding
Death Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Phospholipid Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Cell Apoptotic Process
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Cellular Chloride Ion Homeostasis
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Retinal Cell Programmed Cell Death
Endosomal Lumen Acidification
T Cell Apoptotic Process
Necroptotic Process
Response To Growth Factor
Cellular Response To Interferon-gamma
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum
Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface
Positive Regulation Of Endothelial Cell Apoptotic Process
Adaptive Immune Response
Protein Phosphorylation
Integrin-mediated Signaling Pathway
Regulation Of Platelet Activation
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Tissue Regeneration
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Pathways
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Interleukin-4 and Interleukin-13 signaling
Dimerization of procaspase-8
FasL/ CD95L signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
FOXO-mediated transcription of cell death genes
TNFs bind their physiological receptors
Signaling by SCF-KIT
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs
Fostamatinib
Zanubrutinib
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic sensitization (
30013184
)
Asthma (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
20190752
25920553
24999842
)
Crohn's disease (
21102463
23128233
)
Daytime sleep phenotypes (
27126917
)
Itch intensity from mosquito bite (
28199695
)
Psoriasis (
28537254
)
Systemic lupus erythematosus (
28714469
)
Vitiligo (
27723757
)
Crohn's disease (
23128233
)
Metabolite levels (
23823483
)
Pulse pressure (
27841878
)
Rheumatoid arthritis (
30423114
24390342
)
Systolic blood pressure (
27841878
)
Interacting Genes
82 interacting genes:
APBB1
ARHGAP9
BAIAP2L1
BTK
CACNB3
CACNB4
CRK
CYSRT1
DAXX
DLG2
DMD
DNMBP
DOCK4
ECM1
EPS8L3
EZR
FADD
FAS
FGR
FN1
FNBP1
FYB1
FYN
GRAP
GRAP2
GRB2
HCK
IHO1
ITK
ITSN2
KALRN
KMT2A
KRT33B
KRT40
KRTAP11-1
KRTAP12-3
LCK
LYN
MACC1
MIA
MMP7
MPP4
MYO15A
NCF1
NCK1
NCK2
NCKIPSD
NOTCH2NLA
OSTF1
PACSIN2
PDCD6
PIK3CA
PIK3R1
PIN1
PPIAP11
PRPF40A
PSTPIP1
PTPN13
RGS20
RIMBP3C
SAMSN1
SEC23A
SH3GL3
SH3PXD2A
SH3PXD2B
SH3RF2
SKAP2
SNX33
SNX9
SORBS3
SPTA1
SRC
SRGAP1
SRGAP2
SRGAP3
SUMO1
TEC
TJP3
TNFRSF6B
TNS2
TRIP6
YES1
36 interacting genes:
ARHGEF12
BMX
BTK
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FASLG
FBXO7
GAB1
GNA12
IKBKG
JAK1
JAK2
KIT
LRRK1
LYN
MET
PIK3R1
PIK3R2
PIK3R3
PIP4K2A
PIP5K1A
PLCG1
PLCG2
PLK4
PRLR
PTPN18
PTPN21
SHC1
SOCS1
STAP1
TP53
VAV1
WAS
Entrez ID
356
7006
HPRD ID
00610
02786
Ensembl ID
ENSG00000117560
ENSG00000135605
Uniprot IDs
P48023
Q53ZZ1
P42680
PDB IDs
1BZI
4MSV
5L19
5L36
2LUL
Enriched GO Terms of Interacting Partners
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