TEC and STAP1

Data Source:
HPRD (in vitro, in vivo)

		TEC	STAP1
Description		tec protein tyrosine kinase	signal transducing adaptor family member 1
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Signaling Adaptor Activity
	Biological Process	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Phosphorylation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Cellular Response To Lipopolysaccharide Negative Regulation Of Ruffle Assembly Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Activation Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)	Regular attendance at a pub or social club ( 29970889)
Interacting Genes		36 interacting genes: ARHGEF12 BMX BTK DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS	14 interacting genes: AR EGFR ERBB2 ERBB3 ERBB4 GAB1 GRIPAP1 KIT MET PTK2B RETREG3 SH3KBP1 TEC URI1
Entrez ID		7006	26228
HPRD ID		02786	16053
Ensembl ID		ENSG00000135605	ENSG00000035720
Uniprot IDs		P42680	A0A024RD91 Q9ULZ2
PDB IDs		2LUL	1X1F 3MAZ
Enriched GO Terms of Interacting Partners?
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