FASLG and NCK1

Data Source:
HPRD (in vivo)

		FASLG	NCK1
Description		Fas ligand	NCK adaptor protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Vesicle Lumen Extracellular Exosome	Protein Phosphatase Type 1 Complex Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Plasma Membrane Cell-cell Junction Vesicle Membrane
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Kinase Inhibitor Activity Signaling Receptor Binding Protein Binding Cytoskeletal Anchor Activity Protein Domain Specific Binding Signaling Receptor Complex Adaptor Activity Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Cadherin Binding Ephrin Receptor Binding Eukaryotic Initiation Factor EIF2 Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Cellular Response To Interferon-gamma Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Protein Kinase Activity Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Signal Complex Assembly Positive Regulation Of Neuron Projection Development Lamellipodium Assembly Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Response To Other Organism Negative Regulation Of Cell Death Peptidyl-serine Dephosphorylation Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Interleukin-4 and Interleukin-13 signaling Dimerization of procaspase-8 FasL/ CD95L signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models FOXO-mediated transcription of cell death genes TNFs bind their physiological receptors	Downstream signal transduction Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Nephrin family interactions DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 30013184) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752 25920553 24999842) Crohn's disease ( 21102463 23128233) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Psoriasis ( 28537254) Systemic lupus erythematosus ( 28714469) Vitiligo ( 27723757)	Autism spectrum disorder or schizophrenia ( 28540026) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Blood urea nitrogen levels ( 31152163) Body mass index ( 25673413) Platelet count ( 32888494) Platelet distribution width ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		82 interacting genes: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK CYSRT1 DAXX DLG2 DMD DNMBP DOCK4 ECM1 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB1 FYN GRAP GRAP2 GRB2 HCK IHO1 ITK ITSN2 KALRN KMT2A KRT33B KRT40 KRTAP11-1 KRTAP12-3 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NLA OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SEC23A SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TNS2 TRIP6 YES1	95 interacting genes: ABI1 ABI2 ABL1 ADAM15 ADGRL2 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CHN2 CRK CSNK1G2 CYFIP2 DAG1 DCC DLGAP4 DNM1 DOK1 DOK2 DRD3 DRD4 EFS EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB2 ERBB3 ERBB4 FASLG FCHO1 FGFR1 FLT1 FLT3 FRS2 GAB1 GAB2 GMPPA HOMEZ KDR KHDRBS1 KIAA1522 KIT LCP2 MAP4K1 MAP4K4 MET MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NHSL2 NPHS1 NTRK2 NUTM2F OLIG1 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PIK3AP1 PIK3R3 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SH2D1A SHANK3 SOCS1 SOCS7 SORBS3 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1
Entrez ID		356	4690
HPRD ID		00610	02740
Ensembl ID		ENSG00000117560	ENSG00000158092
Uniprot IDs		P48023 Q53ZZ1	A0A0S2Z4Y3 P16333
PDB IDs		1BZI 4MSV 5L19 5L36	2CI8 2CI9 2CUB 2JS0 2JS2 2JW4 5QU1 5QU2 5QU3 5QU4 5QU5 5QU6 5QU7 5QU8 5QUA
Enriched GO Terms of Interacting Partners?
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