SKA2 and PRKD3

Data Source:
BioGRID (two hybrid)

		SKA2	PRKD3
Description		spindle and kinetochore associated complex subunit 2	protein kinase D3
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GO Annotations	Cellular Component	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule	Nucleoplasm Cytosol Membrane
	Molecular Function	Protein Binding Microtubule Binding	Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division	Protein Phosphorylation Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Sphingolipid Biosynthetic Process Protein Kinase D Signaling
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Cognitive function ( 25644384) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)	Body mass index ( 28892062) Chronic lymphocytic leukemia ( 28165464 24292274) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Pulse pressure ( 27841878) Schizophrenia ( 23974872) Systolic blood pressure ( 28135244 27841878)
Interacting Genes		6 interacting genes: HMOX2 IFT57 PRKD3 RALY SKA1 SPC24	12 interacting genes: BCL6 DLAT GSK3A IKBKG KPNA2 KPNB1 MYH3 NUDT3 POLL SKA2 TAF1 VAMP2
Entrez ID		348235	23683
HPRD ID		13306	06151
Ensembl ID		ENSG00000182628	ENSG00000115825
Uniprot IDs		J3KSP0 Q8WVK7	O94806
PDB IDs		4AJ5	2D9Z
Enriched GO Terms of Interacting Partners?
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